Blar i forfatter "Taman, Hagar"

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    • DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis 

      Taman, Hagar; Fenton, Christopher Graham; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)
      Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between transcriptomic and genome-wide DNA methylation profiles in a well-stratified, treatment-naïve severe UC patient population in order to define specific epigenetic changes that could be responsible for the grade of disease ...

    • Epigenetics in Inflammatory Bowel Disease. Contribution of DNA methylation to Ulcerative Colitis pathogenesis 

      Taman, Hagar (Doctoral thesis; Doktorgradsavhandling, 2022-04-08)
      Ulcerative colitis (UC) is a chronic, inflammatory disease of the gastrointestinal tract, primarily affecting the colon. Along with Crohn’s disease (CD) they constitute the most common subtypes of inflammatory bowel disease (IBD). Genetic variants can only explain approximately 20 % of all IBD cases, indicating a more complex pathogenesis which is not fully understood. It has been implied that an ...

    • Genome-Wide DNA Methylation in Treatment-Naïve Ulcerative Colitis 

      Taman, Hagar; Fenton, Christopher Graham; Hensel, Inga Viktoria; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-22)
      <p><i>Background and Aims</i>: The aim of this study was to investigate the genome-wide DNA methylation status in treatment-naïve ulcerative colitis [UC], and to explore the relationship between DNA methylation patterns and gene expression levels in tissue biopsies from a well-stratified treatment-naïve UC patient group.</p> <p><i>Methods</i>; Mucosal biopsies from treatment-naïve patients [n = ...

    • Transcriptional profiling of ulcerative colitis in remission 

      Fenton, Christopher Graham; Taman, Hagar; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel, 2019-01-25)
      <p><i>Background - </i>This study addresses whether existing transcriptional profiles can improve and support the current definition of UC in remission apart from the today existing endoscopic, histological and laboratory scoring systems. <p><i>Methods - </i>Mucosal biopsies from treatment-naïve UC patients (<i>n</i> = 14), healthy controls (<i>n</i> = 16), and UC patients in remission (<i>n</i> = ...

    • Transcriptional signatures that define ulcerative colitis in remission 

      Fenton, Christopher Graham; Taman, Hagar; Florholmen, Jon; Sørbye, Sveinung; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-23)
      <i>Background</i> - This study addresses whether existing specific transcriptional profiles can improve and support the current status of the definition of ulcerative colitis (UC) remission apart from the existing endoscopic, histologic, and laboratory scoring systems. For that purpose, a well-stratified UC patient population in remission was compared to active UC and control patients and was ...

    • Transcriptomic Landscape of Treatment-Naïve Ulcerative Colitis 

      Taman, Hagar; Fenton, Christopher Graham; Hensel, Inga Viktoria; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-10)
      Background and Aims: Ulcerative colitis [UC] is a chronic inflammatory disease that effects the gastrointestinal tract and is considered one of the most prominent and common forms of inflammatory bowel disease [IBD]. This study aimed to define and describe the entire transcriptomic landscape in a well-stratified, treatment-naïve UC patient population compared ...